Cardiovascular Disease Risk Score Correlates with Glomerular Filtration Rate in Hemodialysis Patients: A Cross-Sectional Pilot Study
DOI:
https://doi.org/10.65310/2v7hr182Keywords:
Chronic Kidney Disease, Cardiovascular Risk, Glomerular Filtration Rate, Hemodialysis, SEAR B Score.Abstract
Chronic kidney disease is closely linked to an elevated risk of cardiovascular morbidity and mortality, particularly among patients undergoing hemodialysis. This study aimed to examine the relationship between cardiovascular disease risk scores and renal function using an empirical cross-sectional design. A total of 72 eligible patients receiving hemodialysis were assessed using the World Health Organization Risk Prediction Chart for Southeast Asia Region B to estimate 10-year cardiovascular risk. Renal function was evaluated using the Cockcroft–Gault equation to determine glomerular filtration rate values. Descriptive analysis demonstrated a predominance of high cardiovascular risk categories alongside severely reduced renal function. Inferential analysis using the Spearman rank correlation test revealed a statistically significant inverse relationship between cardiovascular risk score and glomerular filtration rate (r = -0.637; p = 0.000). These findings indicate that higher cardiovascular risk is associated with more severe renal impairment. The results support the integration of cardiovascular risk assessment into routine clinical evaluation of patients with chronic kidney disease undergoing hemodialysis to improve early risk stratification and management strategies.
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Al-Dwairi, A., Al-Shboul, O., Alqudah, M., & Al-U'Datt, D. A. G. (2025). Determinants of estimated glomerular filtration rate in patients with type 2 diabetes mellitus: A cross-sectional study. Biomedical Reports, 23(6), 194. https://doi.org/10.3892/br.2025.2072
Bhagat, N., Dawman, L., Naganur, S., Tiewsoh, K., Kumar, B., Pratyusha, K., ... & Gupta, K. L. (2022). Impact of anemia on the cardiovascular status in children with chronic kidney disease: A pilot study. Clinical Nutrition ESPEN, 47, 283-287. https://doi.org/10.1016/j.clnesp.2021.11.031
Bjornstad, P., Richard, G., Choi, Y. J., Nowak, K. L., Steele, C., Chonchol, M. B., ... & Gitomer, B. (2024). Kidney energetics and cyst burden in autosomal dominant polycystic kidney disease: a pilot study. American Journal of Kidney Diseases, 84(3), 286-297. https://doi.org/10.1053/j.ajkd.2024.02.016
Cai, J., Zhang, L., Chen, C., Ge, J., Li, M., Zhang, Y., ... & Song, B. (2023). Association between serum Klotho concentration and heart failure in adults, a cross-sectional study from NHANES 2007–2016. International Journal of Cardiology, 370, 236-243. https://doi.org/10.1016/j.ijcard.2022.11.010
Cavalcante, M. G., Gomes, P. E. A. D. C., Parente, M. D. S. R., Meneses, G. C., Silva Junior, G. B. D., Neto, R. D. J. P., ... & Daher, E. D. F. (2023). Monitoring renal function in HIV patients without kidney disease using endothelial biomarkers: a prospective pilot study. AIDS Research and Human Retroviruses, 39(9), 468-474. https://doi.org/10.1089/aid.2022.0113
Cheng, Y., Zhang, H., Zheng, H., Yin, H., Wang, Y., Wang, H., ... & Yin, D. (2022). Association between serum uric acid/HDL-cholesterol ratio and chronic kidney disease: a cross-sectional study based on a health check-up population. BMJ open, 12(12), e066243. https://doi.org/10.1136/bmjopen-2022-066243
Elsawwah, M., Rabie, M. M., Abdelaziz, A. F., & Abdelbaky, M. S. E. (2025). Correlation Between Carotid Artery Intima-Media Thickness and Both Gamma Carboxyglutamic Acid Rich Protein and Glomerular Filtration Rate in Chronic Kidney Disease Children. GEGET, 20(2), 78-87. https://doi.org/10.21608/geget.2025.483570
Etaee, F., Naguib, T., Goldust, M., Daveluy, S., & Maibach, H. (2022). Role of skin autofluorescence in managing renal and cardiac diseases in outpatient dermatology. Skin Research and Technology, 28(6), 889-905. https://doi.org/10.1111/srt.13211
Hsu, P. C., Liao, P. Y., Huang, S. W., Chang, H. H., Chiang, J. Y., & Lo, L. C. (2025). Nailfold capillary abnormalities as indicators of diabetic nephropathy progression: a cross-sectional study in type 2 diabetes. Annals of Medicine, 57(1), 2458766. https://doi.org/10.1080/07853890.2025.2458766
Jiang, J., Huang, W., Lan, L., Zheng, X., Luo, S., Ding, Y., ... & Yang, D. (2025). Related factors for kidney disease and high chronic kidney disease progression risk in adult-onset type 1 diabetes mellitus patients from China: a multi-center cross-sectional study. Renal Failure, 47(1), 2483389. https://doi.org/10.1080/0886022X.2025.2483389
Khudhair, A. S. (2025). Risk factors for chronic kidney disease among haemodialysis patients in Al-Basrah: A cross-sectional study. Babcock University Medical Journal, 8(2), 378-384. https://doi.org/10.38029/babcockuniv.med.j..v8i2.1079
Kvasnička, A., Friedecký, D., Piskláková, B., Rozhon, J., Pavelka, K., & Stibůrková, B. (2025). Ceramide-based risk score: A novel laboratory tool for cardiovascular risk stratification in hyperuricemia and gout. Vascular Pharmacology, 159, 107495. https://doi.org/10.1016/j.vph.2025.107495
Lazarova, M., Urinovska, R., Kacirova, I., Grundmann, M., Dodulik, J., & Vaclavik, J. (2025). Serum concentrations of valsartan and sacubitrilat, the active metabolite of sacubitril, in patients with heart failure with reduced ejection fraction: results of a pilot cross-sectional study. Expert Review of Clinical Pharmacology, 18(6), 397-406. https://doi.org/10.1080/17512433.2025.2519644
Mikuteit, M., Gueler, F., Pollmann, I., Pflugrad, H., Dirks, M., de Zwaan, M., & Weissenborn, K. (2022). Assessment of cognitive functioning after living kidney donation: A cross-sectional pilot study. PLoS One, 17(2), e0264284. https://doi.org/10.1371/journal.pone.0264284
Ministry of Health of the Republic of Indonesia. (2018). The role of government in the prevention and control of kidney disorders. Trop Disease in Indonesia.
Miura, M., Owada, S., Ito, O., & Kohzuki, M. (2025). Safety and efficacy of belt-type electrical stimulation for preventing disuse syndrome in elderly hemodialysis patients: a pilot study. Frontiers in Rehabilitation Sciences, 6, 1559077. https://doi.org/10.3389/fresc.2025.1559077
Ohata, T., Kishikawa, H., Tamaki, A., Matsuzawa, R., Katsuno, T., & Miyamoto, T. (2023). Relationship between physical activity and estimated glomerular filtration rate in renal transplant recipients: a cross-sectional study analyzing isotemporal substitution model. Journal of Renal Nutrition, 33(6), 755-763. https://doi.org/10.1053/j.jrn.2023.05.008
Shan, Y., Lin, M., Gu, F., Ying, S., Bao, X., Zhu, Q., ... & Wang, M. (2023). Association between fasting stress hyperglycemia ratio and contrast-induced acute kidney injury in coronary angiography patients: a cross-sectional study. Frontiers in Endocrinology, 14, 1300373. https://doi.org/10.3389/fendo.2023.1300373
Stehlé, T., Ouamri, Y., Morel, A., Vidal-Petiot, E., Fellahi, S., Segaux, L., ... & Pigneur, F. (2023). Development and validation of a new equation based on plasma creatinine and muscle mass assessed by CT scan to estimate glomerular filtration rate: a cross-sectional study. Clinical kidney journal, 16(8), 1265-1277. https://doi.org/10.1093/ckj/sfad012
Truong, D. Q., Binh, T. Q., Thao, H. N. P., Hoang, T. M., Trang, N. T. T., Nhat, P. T. H., & Khoi, L. M. (2026). Risk Factors for Impaired Left Ventricular Global Longitudinal Strain in Chronic Kidney Disease Patients: A Cross-Sectional Study. Journal of Diagnostic Medical Sonography, 42(2), 111-119. https://doi.org/10.1177/87564793251380854
Wang, Y., Zhou, Z., Han, X., Ji, G., Li, H., & An, Z. (2026). Association Between Life's Crucial 9 and the Risk of Chronic Kidney Disease: A Cross-Sectional Study from NHANES 2005 to 2018. medRxiv, 2026-02. https://doi.org/10.64898/2026.02.02.26345422
World Health Organization (WHO). (2007). Prevention of cardiovascular disease: Pocket guidelines for assessment and management of cardiovascular risk. WHO Press.
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Copyright (c) 2026 Nabil Hajar, Bintang Adhiyoso Wicaksono, Zulfachmi Wahab, Shofa Chasani, Galih Prakasa Adhyatma, Nabila Nuralya Joveazhari, Zeidan Ahmad Fahdalhaq (Author)
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